Case Study: 62 year-old woman with N-cadherin positive esophageal cancer

A 62-year old woman with N-cadherin positive esophageal cancer and metastases in the lung had previously received and was unresponsive to chemotherapy and radiation therapy. Four weeks following the initial dose of ADH-1, her lung metastases had reduced in size by 48%. This patient went on to receive additional doses of ADH-1 and, after three months, her lung metastases had reduced in size by 65%. The scans below show the lesions before receiving ADH-1 on the left and the tumors after three cycles of ADH-1 on the right. In total, this patient received 11 doses of ADH-1, maintained the 65% reduction in tumor size for six months, and did not experience tumor progression for nine months.