Patents

Adherex believes that part of its success will be based on effective intellectual property protection and having the right team working to develop these patents. Adherex protects its main asset with a comprehensive patent portfolio, including the following U.S. patents:

2008

Compounds and methods for regulating cell adhesion   
Issued 02/05/08

Method protection for using linear modulating agents to enhance or inhibit cadherin-mediated cell adhesion
US Patent No. 7,326,686 

2007

Peptidomimetic Modulators of Cell Adhesion
Issued 09/11/07
Method protection for using peptidomimetics of ADH-1 for modulating cadherin-mediated cell adhesion
US Patent No. 7,268,115

2006

Compounds and methods for modulating apoptosis
Issued 11/21/06
Method protection for inducing apoptosis in cadherin-expressing cells
US Patent No. 7,138,369

Compounds and methods for modulating cell adhesion
Issued 10/17/06
Method protection for inhibiting vascular smooth muscle cell migration and enhancing vascular smooth muscle cell apoptosis
US Patent No. 7,122,623

Uracil Reductase Inactivators
Issued 10/10/06
Compound protection for eniluracil
US Patent No. 7,119,096

Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 6/20/06
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 7,063,842

2005

Compounds and methods for modulating cell adhesion
Issued 11/22/05
Methods for stimulating blood vessel regression
US Patent No.  6,967,238

Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 11/08/05
Method protection for inhibiting or enhancing nonclassical cadherin mediated cell adhesion
US Patent No. 6,962,969

Compounds and methods for modulating cell adhesion
Issued 07/05/05
Method protection for modulating cadherin-mediated cell adhesion and targeting or detecting cadherin-expressing cells in a variety of contexts with Adherex compounds
US Patent No. 6,914,044

2004

Compounds and methods for modulating claudin-mediated function
Issued 12/14/04
Method protection for enhancing or inhibiting claudin-mediated cell adhesion
US Patent No. 6,830,894

Compounds and methods for modulating adhesion molecule function
Issued 10/19/04
Compound protection for enhancing or inhibiting cadherin-mediated adhesion
US Patent No. 6,806,255

Compounds and methods for cancer therapy
Issued 9/28/04
Method protection for enhancing drug delivery to tumors
U.S. Patent No. 6,797,807

Compounds and methods for cancer therapy
Issued 8/24/04
Method protection for decreasing tumor size
U.S Patent No. 6,780,845

Compounds and methods for modulating claudin-mediated functions
Issued 6/29/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,756,356

Compounds and methods for modulating claudin-mediated functions
Issued 4/20/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,723,700

Compounds and methods for stimulating beta-catenin mediated expression and differentiation
Issued 3/16/04
Method protection for stimulating activation of gene transcription in a cell, comprising contacting a cell with a modulating agent that inhibits degradation of cytoplasmic beta-catenin
US Patent No. 6,706,685

Compounds and methods for stimulating gene expression and cellular differentiation
Issued 1/27/04
Method protection relating to increasing the level of free beta-catenin in a cell, comprising contacting a cell with a sufficient amount of a modulating agent effective to inhibit an interaction between alpha-catenin and beta-catenin
US Patent No. 6,683,048

Methods for diagnosing and evaluating cancer
Issued 1/27/04
Method protection for monitoring the progression of ovarian cancer in a patient using binding agents that specifically bind to N-cadherin
US Patent No. 6,682,901

Methods for diagnosing and evaluating cancer
Issued 1/20/04
Method protection for diagnosing, monitoring the progression of and evaluating the metastatic potential of a cancer using binding agents that specifically bind to OB-cadherin
US Patent No. 6,680,175

Methods for treating cancer by modulating beta-catenin mediated gene expression
Issued 1/13/04
Method protection for modulating agents that inhibit beta-catenin mediated gene expression
US Patent No. 6,677,116

2003

Compounds and methods for modulating desmosomal cadherin-mediated functions
Issued 10/28/03
Compound protection for modulating agents that inhibit or enhance desmosomal cadherin-mediated cell adhesion
US Patent No. 6,638,911

Compounds and methods for modulating endothelial cell adhesion
Issued 8/26/03
Method protection for modulating cadherin-mediated endothelial cell functions
US Patent No. 6,610,821

Compounds and methods for inhibiting cancer metastasis
Issued 7/15/03
Method protection for inhibiting metastasis of OB-cadherin expressing cancer cells
US Patent No. 6,593,297

Compounds and methods for modulating VE-cadherin mediated cell adhesion
Issued 5/27/03
Compound protection for antibodies that bind to the VE-cadherin cell adhesion recognition sequence
US Patent No. 6,569,996

Compounds and methods for modulating apoptosis
Issued 5/13/03
Methods for modulating apoptosis using cyclic peptides comprising the HAV motif
US Patent No. 6,562,786

Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 4/22/03
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 6,551,994

2002

Compounds and methods for modulating adhesion molecule function
Issued 10/29/02
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,472,368

Compounds and methods for modulating OB-cadherin mediated cell adhesion
Issued 10/29/02
Compound protection for OB-cadherin inhibitors
US Patent No. 6,472,367

Compounds and methods for modulating cell adhesion
Issued 10/15/02
Method protection for treating cancer with ADH-1-related compounds
US Patent No. 6,465,427

Compounds and methods for inhibiting cancer metastasis
Issued 8/13/02
Method protection for the use of OB-cadherin based agents as inhibitors of cancer metastasis
US Patent No. 6,433,149

Compounds and methods for cancer therapy
Issued 7/9/02
Method protection for treating cancer with ADH-1and related compounds
US Patent No. 6,417,325

Compounds and methods for modulating junctional adhesion molecule-mediated functions
Issued 5/21/02
Compound protection for JAM cell adhesion recognition sequence modulating agents
US Patent No. 6,391,855

Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 3/19/02
Compound protection for cadherin based peptides that inhibit the development of cancer and tumor growth
US Patent No. 6,358,920

Compounds and methods for modulating cell adhesion
Issued 2/12/02
Method protection for enhancing drug delivery to the central nervous system with Adherex compounds
US Patent No. 6,346,512

2001

Compounds and methods for modulating neurite outgrowth
Issued 12/25/01
Method protection for treating spinal cord injury with Adherex compounds
US Patent No. 6,333,307

Compounds and methods for modulating cell adhesion
Issued 12/4/01
Compound protection for pharmaceutical compositions containing ADH-1and related molecules; method protection for enhancing drug delivery and wound healing with Adherex compounds
US Patent No. 6,326,352

Compounds and methods for modulating tissue permeability
Issued 10/30/01
Additional compound protection for Adherex' occludin-inhibiting compounds and for antibodies against those compounds
US Patent No. 6,310,177

Compounds and methods for compounds and methods for modulating beta-catenin mediated gene expression
Issued 10/16/01
Method protection for modulating beta-catenin mediated gene expression
US Patent No. 6,303,576

Compounds and methods for modulating adhesion molecule function
Issued 8/21/01
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,277,824

Uracil Reductase Inactivators
Issued 07/31/01
Compound protection for eniluracil in combination with 5-fluorouracil (5-FU) and 5-FU prodrugs
US Patent No. 6,268,374

Compounds and methods for modulating tissue permeability
Issued 6/19/01
Compound protection for Adherex' occludin-inhibiting compounds
US Patent No. 6,248,864

Compounds and methods for modulating neurite outgrowth
Issued 3/27/01
Method protection for affecting nerve cell growth with Adherex compounds
US Patent No. 6,207,639

Compounds and methods for regulating cell adhesion
Issued 3/20/01
Method protection for treating demyelinating diseases such as multiple sclerosis with cadherin-modulating peptides
US Patent No. 6,203,788

Compounds and methods for modulating cell adhesion
Issued 1/2/01
Method protection for affecting cell adhesion with ADH-1and related compounds
US Patent No. 6,169,071

2000

Compounds and methods for modulating tissue permeability
Issued 8/29/00
Method protection for identifying occluding-inhibiting compounds by screening with antibodies against Adherex' occludin-inhibiting compounds
US Patent No. 6,110,747

Compounds and methods for modulating cell adhesion
Issued 2/29/00
Compound protection for ADH-1and related molecules
US Patent No. 6,031,072

1992

Differential delivery of therapeutic agents across the blood brain barrier
Issued 6/23/92
Method protection for drug delivery to brain tumors
US Patent No. 5,124,146

1991

Method for diagnostically imaging lesions in the brain inside a blood brain barrier
Issued 10/22/91
Method protection for imaging brain tumors
US Patent No. 5,059,415

1989