VE-Cadherin Antagonists

VE-cadherin is a cell-cell adhesion molecule present in the endothelium of blood vessels and is responsible for maintaining vascular integrity and remodeling the vascular tree. Mice that lack this adhesion molecule form unstable blood vessels and die, highlighting the key role played by VE-cadherin in the vasculature. Function-blocking antibodies to VE-cadherin disrupt endothelial cell adhesion, cause angiolysis and inhibit angiogenesis.

Adherex has developed peptide VE-cadherin antagonists which have the potential to be synergistic with our N-cadherin antagonists.