Patents


Adherex believes that part of its success will be based on effective intellectual property protection and having the right team working to develop these patents. Adherex protects its main asset with a comprehensive patent portfolio, including the following U.S. patents:

 

2009

 

Compounds and methods for modulating OB-cadherin-mediated function

Issued 01/27/09    

Compound protection for antibodies capable of modulating OB-cadherin mediated cell adhesion

US Patent No. 7,481,999   

 

2008

Compounds and methods for modulating functions of classical cadherins   

Issued 11/25/08    

Compound protection for tryptophan-containing modulator of cadherin-mediated cell adhesion

US Patent No. 7,456,153 

 

Peptidomimetic modulators of cell adhesion   

Issued 11/04/08 

Method protection for using peptidomimetics of ADH-1 for modulating cadherin-mediated cell adhesion
US Patent No. 7,446,120 

 

Compounds and methods for regulating cell adhesion   
Issued 02/05/08

Method protection for using linear modulating agents to enhance or inhibit cadherin-mediated cell adhesion
US Patent No. 7,326,686 

 

2007

 

Peptidomimetic Modulators of Cell Adhesion
Issued 09/11/07
Method protection for using peptidomimetics of ADH-1 for modulating cadherin-mediated cell adhesion
US Patent No. 7,268,115

 

2006

 

Compounds and methods for modulating apoptosis
Issued 11/21/06
Method protection for inducing apoptosis in cadherin-expressing cells
US Patent No. 7,138,369

 

Compounds and methods for modulating cell adhesion
Issued 10/17/06
Method protection for inhibiting vascular smooth muscle cell migration and enhancing vascular smooth muscle cell apoptosis
US Patent No. 7,122,623

 

Uracil Reductase Inactivators
Issued 10/10/06
Compound protection for eniluracil
US Patent No. 7,119,096

 

Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 6/20/06
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 7,063,842

 

2005

 

Compounds and methods for modulating cell adhesion
Issued 11/22/05
Methods for stimulating blood vessel regression
US Patent No.  6,967,238

 

Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 11/08/05
Method protection for inhibiting or enhancing nonclassical cadherin mediated cell adhesion
US Patent No. 6,962,969

 

Compounds and methods for modulating cell adhesion
Issued 07/05/05
Method protection for modulating cadherin-mediated cell adhesion and targeting or detecting cadherin-expressing cells in a variety of contexts with Adherex compounds
US Patent No. 6,914,044

 

2004

 

Compounds and methods for modulating claudin-mediated function
Issued 12/14/04
Method protection for enhancing or inhibiting claudin-mediated cell adhesion
US Patent No. 6,830,894

 

Compounds and methods for modulating adhesion molecule function
Issued 10/19/04
Compound protection for enhancing or inhibiting cadherin-mediated adhesion
US Patent No. 6,806,255

 

Compounds and methods for cancer therapy
Issued 9/28/04
Method protection for enhancing drug delivery to tumors
U.S. Patent No. 6,797,807

 

Compounds and methods for cancer therapy
Issued 8/24/04
Method protection for decreasing tumor size
U.S Patent No. 6,780,845

 

Compounds and methods for modulating claudin-mediated functions
Issued 6/29/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,756,356

 

Compounds and methods for modulating claudin-mediated functions
Issued 4/20/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,723,700

 

Compounds and methods for stimulating beta-catenin mediated expression and differentiation
Issued 3/16/04
Method protection for stimulating activation of gene transcription in a cell, comprising contacting a cell with a modulating agent that inhibits degradation of cytoplasmic beta-catenin
US Patent No. 6,706,685

 

Compounds and methods for stimulating gene expression and cellular differentiation
Issued 1/27/04
Method protection relating to increasing the level of free beta-catenin in a cell, comprising contacting a cell with a sufficient amount of a modulating agent effective to inhibit an interaction between alpha-catenin and beta-catenin
US Patent No. 6,683,048

 

Methods for diagnosing and evaluating cancer
Issued 1/27/04
Method protection for monitoring the progression of ovarian cancer in a patient using binding agents that specifically bind to N-cadherin
US Patent No. 6,682,901

 

Methods for diagnosing and evaluating cancer
Issued 1/20/04
Method protection for diagnosing, monitoring the progression of and evaluating the metastatic potential of a cancer using binding agents that specifically bind to OB-cadherin
US Patent No. 6,680,175

 

Methods for treating cancer by modulating beta-catenin mediated gene expression
Issued 1/13/04
Method protection for modulating agents that inhibit beta-catenin mediated gene expression
US Patent No. 6,677,116

 

2003

 

Compounds and methods for modulating desmosomal cadherin-mediated functions
Issued 10/28/03
Compound protection for modulating agents that inhibit or enhance desmosomal cadherin-mediated cell adhesion
US Patent No. 6,638,911

 

Compounds and methods for modulating endothelial cell adhesion
Issued 8/26/03
Method protection for modulating cadherin-mediated endothelial cell functions
US Patent No. 6,610,821

 

Compounds and methods for inhibiting cancer metastasis
Issued 7/15/03
Method protection for inhibiting metastasis of OB-cadherin expressing cancer cells
US Patent No. 6,593,297

 

Pharmaceutical compositions of 5-alkynyl uracil compounds

Issued 7/01/03

Pharmaceutical compositions of 5-alkynyluracil compounds in the form of tablets or capsules

US Patent No. 6,586,440

 

Compounds and methods for modulating VE-cadherin mediated cell adhesion
Issued 5/27/03
Compound protection for antibodies that bind to the VE-cadherin cell adhesion recognition sequence

US Patent No. 6,569,996

 

Compounds and methods for modulating apoptosis
Issued 5/13/03
Methods for modulating apoptosis using cyclic peptides comprising the HAV motif
US Patent No. 6,562,786

 

Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 4/22/03
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 6,551,994

 

2002

 

Compounds and methods for modulating adhesion molecule function
Issued 10/29/02
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,472,368

 

Compounds and methods for modulating OB-cadherin mediated cell adhesion
Issued 10/29/02
Compound protection for OB-cadherin inhibitors
US Patent No. 6,472,367

 

Compounds and methods for modulating cell adhesion
Issued 10/15/02
Method protection for treating cancer with ADH-1-related compounds
US Patent No. 6,465,427

 

Compounds and methods for inhibiting cancer metastasis
Issued 8/13/02
Method protection for the use of OB-cadherin based agents as inhibitors of cancer metastasis
US Patent No. 6,433,149

 

Compounds and methods for cancer therapy
Issued 7/9/02
Method protection for treating cancer with ADH-1and related compounds
US Patent No. 6,417,325

 

Compounds and methods for modulating junctional adhesion molecule-mediated functions
Issued 5/21/02
Compound protection for JAM cell adhesion recognition sequence modulating agents
US Patent No. 6,391,855

 

Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 3/19/02
Compound protection for cadherin based peptides that inhibit the development of cancer and tumor growth
US Patent No. 6,358,920

 

Compounds and methods for modulating cell adhesion
Issued 2/12/02
Method protection for enhancing drug delivery to the central nervous system with Adherex compounds

US Patent No. 6,346,512

 

2001

 

Compounds and methods for modulating neurite outgrowth
Issued 12/25/01
Method protection for treating spinal cord injury with Adherex compounds
US Patent No. 6,333,307

 

Compounds and methods for modulating cell adhesion
Issued 12/4/01
Compound protection for pharmaceutical compositions containing ADH-1and related molecules; method protection for enhancing drug delivery and wound healing with Adherex compounds
US Patent No. 6,326,352

 

Compounds and methods for modulating tissue permeability
Issued 10/30/01
Additional compound protection for Adherex' occludin-inhibiting compounds and for antibodies against those compounds
US Patent No. 6,310,177

 

Compounds and methods for compounds and methods for modulating beta-catenin mediated gene expression
Issued 10/16/01
Method protection for modulating beta-catenin mediated gene expression
US Patent No. 6,303,576

 

Uracil reductase inactivators

Issued 10/02/01

Methods of using uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, to enhance the activity of 5-fluorouracil (5-FU) or prodrugs thereof, particularly in the treatment of cancer
US Patent No. 6,297,223

 

Compounds and methods for modulating adhesion molecule function
Issued 8/21/01
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,277,824

 

Uracil Reductase Inactivators
Issued 07/31/01
Compound protection for eniluracil in combination with 5-fluorouracil (5-FU) and 5-FU prodrugs
US Patent No. 6,268,374

 

Compounds and methods for modulating tissue permeability
Issued 6/19/01
Compound protection for Adherex' occludin-inhibiting compounds
US Patent No. 6,248,864

 

Pharmaceutical compositions of 5-alkynyl-dideoxyribouracil

Issued 4/24/01

Pharmaceutical compositions of 5-alkynyl-dideoxyridbouracils which generates 5-alkynyluracils in vivo, which are inactivators of uracil reductase

US Patent No. 6,221,852

 

Compounds and methods for modulating neurite outgrowth
Issued 3/27/01
Method protection for affecting nerve cell growth with Adherex compounds
US Patent No. 6,207,639

 

Compounds and methods for regulating cell adhesion
Issued 3/20/01
Method protection for treating demyelinating diseases such as multiple sclerosis with cadherin-modulating peptides
US Patent No. 6,203,788

 

Pharmaceutical compositions of 5-alkynyl uracil compounds

Issued 1/23/01

Pharmaceutical compositions of 5-alkynuracil

US Patent No. 6,177,436

 

Compounds and methods for modulating cell adhesion
Issued 1/2/01
Method protection for affecting cell adhesion with ADH-1and related compounds
US Patent No. 6,169,071

 

2000

 

Compounds and methods for modulating tissue permeability
Issued 8/29/00
Method protection for identifying occluding-inhibiting compounds by screening with antibodies against Adherex' occludin-inhibiting compounds
US Patent No. 6,110,747

 

Compounds and methods for modulating cell adhesion
Issued 2/29/00
Compound protection for ADH-1and related molecules
US Patent No. 6,031,072

  

1998

 

Uracil reductase inactivators

Issued 10/06/98

Methods of using 5-substituted uracil derivatives as inactivators of uracil reductase which are particularly useful in cancer chemotherapy, especially in combination with antimetabolite antineoplastic agents such as 5-fluorouracil (5-FU)

US Patent No. 5,817,664

 

1997

 

Pharmaceutical compositions of 5-substituted uracil compounds
Issued 7/01/97
Pharmaceutical compositions containing 5-substituted uracil compounds
US Patent No. 5,643,913

 

1992

 

Differential delivery of therapeutic agents across the blood brain barrier
Issued 6/23/92
Method protection for drug delivery to brain tumors
US Patent No. 5,124,146

 

1991

 

Method for diagnostically imaging lesions in the brain inside a blood brain barrier
Issued 10/22/91
Method protection for imaging brain tumors
US Patent No. 5,059,415

 

1989

 

Method for the delivery of genetic material across the blood brain barrier
Issued 9/12/89
Method protection for gene transfer into the brain
US Patent No. 4,866,042