Adherex believes that part of its success will be based on effective intellectual property protection and having the right team working to develop these patents. Adherex protects its main asset with a comprehensive patent portfolio, including the following U.S. patents:
2009
Compounds and methods for modulating OB-cadherin-mediated function
Issued 01/27/09
Compound protection for antibodies capable of modulating OB-cadherin mediated cell adhesion
US Patent No. 7,481,999
2008
Compounds and methods for modulating functions of classical cadherins
Issued 11/25/08
Compound protection for tryptophan-containing modulator of cadherin-mediated cell adhesion
US Patent No. 7,456,153
Peptidomimetic modulators of cell adhesion
Issued 11/04/08
Method protection for using peptidomimetics of ADH-1 for modulating cadherin-mediated cell adhesion
US Patent No. 7,446,120
Compounds and methods for regulating cell adhesion
Issued 02/05/08
Method protection for using linear modulating agents to enhance or inhibit cadherin-mediated cell adhesion
US Patent No. 7,326,686
2007
Peptidomimetic Modulators of Cell Adhesion
Issued 09/11/07
Method protection for using peptidomimetics of ADH-1 for modulating cadherin-mediated cell adhesion
US Patent No. 7,268,115
2006
Compounds and methods for modulating apoptosis
Issued 11/21/06
Method protection for inducing apoptosis in cadherin-expressing cells
US Patent No. 7,138,369
Compounds and methods for modulating cell adhesion
Issued 10/17/06
Method protection for inhibiting vascular smooth muscle cell migration and enhancing vascular smooth muscle cell apoptosis
US Patent No. 7,122,623
Uracil Reductase Inactivators
Issued 10/10/06
Compound protection for eniluracil
US Patent No. 7,119,096
Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 6/20/06
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 7,063,842
2005
Compounds and methods for modulating cell adhesion
Issued 11/22/05
Methods for stimulating blood vessel regression
US Patent No. 6,967,238
Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 11/08/05
Method protection for inhibiting or enhancing nonclassical cadherin mediated cell adhesion
US Patent No. 6,962,969
Compounds and methods for modulating cell adhesion
Issued 07/05/05
Method protection for modulating cadherin-mediated cell adhesion and targeting or detecting cadherin-expressing cells in a variety of contexts with Adherex compounds
US Patent No. 6,914,044
2004
Compounds and methods for modulating claudin-mediated function
Issued 12/14/04
Method protection for enhancing or inhibiting claudin-mediated cell adhesion
US Patent No. 6,830,894
Compounds and methods for modulating adhesion molecule function
Issued 10/19/04
Compound protection for enhancing or inhibiting cadherin-mediated adhesion
US Patent No. 6,806,255
Compounds and methods for cancer therapy
Issued 9/28/04
Method protection for enhancing drug delivery to tumors
U.S. Patent No. 6,797,807
Compounds and methods for cancer therapy
Issued 8/24/04
Method protection for decreasing tumor size
U.S Patent No. 6,780,845
Compounds and methods for modulating claudin-mediated functions
Issued 6/29/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,756,356
Compounds and methods for modulating claudin-mediated functions
Issued 4/20/04
Compound protection for modulating certain claudin-mediated adhesion
US Patent No. 6,723,700
Compounds and methods for stimulating beta-catenin mediated expression and differentiation
Issued 3/16/04
Method protection for stimulating activation of gene transcription in a cell, comprising contacting a cell with a modulating agent that inhibits degradation of cytoplasmic beta-catenin
US Patent No. 6,706,685
Compounds and methods for stimulating gene expression and cellular differentiation
Issued 1/27/04
Method protection relating to increasing the level of free beta-catenin in a cell, comprising contacting a cell with a sufficient amount of a modulating agent effective to inhibit an interaction between alpha-catenin and beta-catenin
US Patent No. 6,683,048
Methods for diagnosing and evaluating cancer
Issued 1/27/04
Method protection for monitoring the progression of ovarian cancer in a patient using binding agents that specifically bind to N-cadherin
US Patent No. 6,682,901
Methods for diagnosing and evaluating cancer
Issued 1/20/04
Method protection for diagnosing, monitoring the progression of and evaluating the metastatic potential of a cancer using binding agents that specifically bind to OB-cadherin
US Patent No. 6,680,175
Methods for treating cancer by modulating beta-catenin mediated gene expression
Issued 1/13/04
Method protection for modulating agents that inhibit beta-catenin mediated gene expression
US Patent No. 6,677,116
2003
Compounds and methods for modulating desmosomal cadherin-mediated functions
Issued 10/28/03
Compound protection for modulating agents that inhibit or enhance desmosomal cadherin-mediated cell adhesion
US Patent No. 6,638,911
Compounds and methods for modulating endothelial cell adhesion
Issued 8/26/03
Method protection for modulating cadherin-mediated endothelial cell functions
US Patent No. 6,610,821
Compounds and methods for inhibiting cancer metastasis
Issued 7/15/03
Method protection for inhibiting metastasis of OB-cadherin expressing cancer cells
US Patent No. 6,593,297
Pharmaceutical compositions of 5-alkynyl uracil compounds
Issued 7/01/03
Pharmaceutical compositions of 5-alkynyluracil compounds in the form of tablets or capsules
US Patent No. 6,586,440
Compounds and methods for modulating VE-cadherin mediated cell adhesion
Issued 5/27/03
Compound protection for antibodies that bind to the VE-cadherin cell adhesion recognition sequence
US Patent No. 6,569,996
Compounds and methods for modulating apoptosis
Issued 5/13/03
Methods for modulating apoptosis using cyclic peptides comprising the HAV motif
US Patent No. 6,562,786
Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
Issued 4/22/03
Compound protection for alpha-catenin and beta-catenin inhibiting compounds
US Patent No. 6,551,994
2002
Compounds and methods for modulating adhesion molecule function
Issued 10/29/02
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,472,368
Compounds and methods for modulating OB-cadherin mediated cell adhesion
Issued 10/29/02
Compound protection for OB-cadherin inhibitors
US Patent No. 6,472,367
Compounds and methods for modulating cell adhesion
Issued 10/15/02
Method protection for treating cancer with ADH-1-related compounds
US Patent No. 6,465,427
Compounds and methods for inhibiting cancer metastasis
Issued 8/13/02
Method protection for the use of OB-cadherin based agents as inhibitors of cancer metastasis
US Patent No. 6,433,149
Compounds and methods for cancer therapy
Issued 7/9/02
Method protection for treating cancer with ADH-1and related compounds
US Patent No. 6,417,325
Compounds and methods for modulating junctional adhesion molecule-mediated functions
Issued 5/21/02
Compound protection for JAM cell adhesion recognition sequence modulating agents
US Patent No. 6,391,855
Compounds and methods for modulating nonclassical cadherin-mediated functions
Issued 3/19/02
Compound protection for cadherin based peptides that inhibit the development of cancer and tumor growth
US Patent No. 6,358,920
Compounds and methods for modulating cell adhesion
Issued 2/12/02
Method protection for enhancing drug delivery to the central nervous system with Adherex compounds
US Patent No. 6,346,512
2001
Compounds and methods for modulating neurite outgrowth
Issued 12/25/01
Method protection for treating spinal cord injury with Adherex compounds
US Patent No. 6,333,307
Compounds and methods for modulating cell adhesion
Issued 12/4/01
Compound protection for pharmaceutical compositions containing ADH-1and related molecules; method protection for enhancing drug delivery and wound healing with Adherex compounds
US Patent No. 6,326,352
Compounds and methods for modulating tissue permeability
Issued 10/30/01
Additional compound protection for Adherex' occludin-inhibiting compounds and for antibodies against those compounds
US Patent No. 6,310,177
Compounds and methods for compounds and methods for modulating beta-catenin mediated gene expression
Issued 10/16/01
Method protection for modulating beta-catenin mediated gene expression
US Patent No. 6,303,576
Uracil reductase inactivators
Issued 10/02/01
Methods of using uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, to enhance the activity of 5-fluorouracil (5-FU) or prodrugs thereof, particularly in the treatment of cancer
US Patent No. 6,297,223
Compounds and methods for modulating adhesion molecule function
Issued 8/21/01
Compound protection for cadherin-inhibiting compounds distinct from ADH-1
US Patent No. 6,277,824
Uracil Reductase Inactivators
Issued 07/31/01
Compound protection for eniluracil in combination with 5-fluorouracil (5-FU) and 5-FU prodrugs
US Patent No. 6,268,374
Compounds and methods for modulating tissue permeability
Issued 6/19/01
Compound protection for Adherex' occludin-inhibiting compounds
US Patent No. 6,248,864
Pharmaceutical compositions of 5-alkynyl-dideoxyribouracil
Issued 4/24/01
Pharmaceutical compositions of 5-alkynyl-dideoxyridbouracils which generates 5-alkynyluracils in vivo, which are inactivators of uracil reductase
US Patent No. 6,221,852
Compounds and methods for modulating neurite outgrowth
Issued 3/27/01
Method protection for affecting nerve cell growth with Adherex compounds
US Patent No. 6,207,639
Compounds and methods for regulating cell adhesion
Issued 3/20/01
Method protection for treating demyelinating diseases such as multiple sclerosis with cadherin-modulating peptides
US Patent No. 6,203,788
Pharmaceutical compositions of 5-alkynyl uracil compounds
Issued 1/23/01
Pharmaceutical compositions of 5-alkynuracil
US Patent No. 6,177,436
Compounds and methods for modulating cell adhesion
Issued 1/2/01
Method protection for affecting cell adhesion with ADH-1and related compounds
US Patent No. 6,169,071
2000
Compounds and methods for modulating tissue permeability
Issued 8/29/00
Method protection for identifying occluding-inhibiting compounds by screening with antibodies against Adherex' occludin-inhibiting compounds
US Patent No. 6,110,747
Compounds and methods for modulating cell adhesion
Issued 2/29/00
Compound protection for ADH-1and related molecules
US Patent No. 6,031,072
1998
Uracil reductase inactivators
Issued 10/06/98
Methods of using 5-substituted uracil derivatives as inactivators of uracil reductase which are particularly useful in cancer chemotherapy, especially in combination with antimetabolite antineoplastic agents such as 5-fluorouracil (5-FU)
US Patent No. 5,817,664
1997
Pharmaceutical compositions of 5-substituted uracil compounds
Issued 7/01/97
Pharmaceutical compositions containing 5-substituted uracil compounds
US Patent No. 5,643,913
1992
Differential delivery of therapeutic agents across the blood brain barrier
Issued 6/23/92
Method protection for drug delivery to brain tumors
US Patent No. 5,124,146
1991
Method for diagnostically imaging lesions in the brain inside a blood brain barrier
Issued 10/22/91
Method protection for imaging brain tumors
US Patent No. 5,059,415
1989
Method for the delivery of genetic material across the blood brain barrier
Issued 9/12/89
Method protection for gene transfer into the brain
US Patent No. 4,866,042
